Doctors might one day be able to harvest cells from patients’ noses to produce cartilage that can be transplanted into damaged knee joints, a small experiment suggests.
Because the experiment only included 10 adults who were followed for just two years, it’s impossible to say for sure whether this procedure would be safe or effective with widespread use. But the results are promising enough to merit more testing, says study co-author Ivan Martin of the University of Basel in Switzerland.
“We have developed a new promising approach to the treatment of articular cartilage injuries,” Martin says by email. “Before this can be offered to patients as a standard treatment, obviously it needs to be tested in larger patient cohorts and in randomized and controlled trials with long-term assessment of clinical outcome.”
Previous research has found cells extracted from the septum can be used to grow new cartilage in a lab, Martin says. With the current experiment, researchers successfully implanted this lab-grown tissue into knee joints for the first time, he says.
To do this, researchers first performed a minimally invasive procedure using local anesthesia to harvest a small specimen, about 6 mm or a quarter of an inch, of tissue from the nasal septum.
Next, they grew the harvested cells in a lab for two weeks, then cultured them for another two weeks on a collagen membrane scaffold to grow thin sheets of cartilage measuring 30 mm by 40 mm, or about 1.2 inches by 1.5 inches.
Researchers trimmed these grafts to the right shape to replace the damaged cartilage removed from each patient’s knee joint, then implanted the replacement tissue.
Two years after reconstructive surgery, most recipients reported improvements in pain, knee function and quality of life, researchers reported Oct. 22 in The Lancet.
MRI scans at two years also showed the growth of new tissue similar to native knee cartilage around where the replacement tissue was implanted, the study found.
Researchers didn’t see any adverse reactions or dangerous side effects.
Every year, around 2 million people in the U.S. and Europe alone are diagnosed with damage to articular cartilage because of injuries or accidents, the researchers note.
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