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Sodium Pentosan Polysulfate for knee osteoarthritis

Kumagai K et al. – The objective of this study was to assess the efficacy, safety, and patient satisfaction in patients with mild radiographic knee OA findings and OA-associated symptoms and signs. Pentosan treatment in twenty patients with mild knee OA seemed to provide improvements in clinical assessments and C2C level of cartilage metabolism.

Methods

  • 20 patients were assessed clinically at Nagasaki University Hospital
  • Radiographic indications of OA were grade 1 to 3 using the Kellgren-Lawrence Grading System (K/L grade)
  • Pentosan used was manufactured and supplied in sterile injectable vials (100mg/ml) by bene GmbH, Munich, Germany
  • Single-center, open-label trial
  • Treatment consisted of 6 weekly subcutaneous injections (sc) of pentosan (2mg/kg)
  • Patients clinically assessed at entry and 1 to 8, 11, 15, 24 & 52 weeks post treatment
  • Results analyzed using one way ANOVA and Dunnett’s method

Results

  • Hydrarthroses reduced quickly in all cases
  • Clinical assessments, i.e., knee flexion, pain while walking, pain after climbing up and down stairs, etc, were improved significantly and these clinical improvements continued for almost one year
  • Dose used affected the blood coagulation test, but was within safe levels
  • Slightly abnormal findings in serum triglycerides

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This web site is run by an Arthritis Specialist based in Dubai, United Arab Emirates. On this site you will find news about the latest in arthritis, information about research results in the field, tips and information and diet and exercise, and much more.

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