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Broccoli offers hope for osteoarthritis

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An artificial version of an ingredient in broccoli – Sulforadex (SFX-01) – is now proving to be an effective treatment for osteoarthritis, according to researchers.

Previous research had found that sulforophane – a compound found in broccoli, was proven to block the inflammation and damage to cartilage associated with osteoarthritis. Researchers from the University of East Anglia in the U.K. had suggested that sulforaphane has anti-inflammatory properties, in a first major study into its effects on joint health. The study, published in the journal ‘Arthritis and Rheumatism’, found that sulforaphane blocks the enzymes that cause joint destruction.

But on the flip side, patients would have to eat a great deal of the vegetable every day to derive any significant benefit. Sulforophane in its natural form was also too unstable to turn into a medicine.

Medical breakthrough

A stable synthetic version of sulforaphane has now been developed by the UK drug company Evgen Pharma and it offers the potential of a pill treatment. A single dose of the drug, known as Sulforadex or SFX-01, is equivalent to eating around 2.5 kilograms (5.5 pounds) of broccoli in one day.

In tests on mice affected by osteoarthritis, Sulforadex significantly improved bone architecture, gait balance and movement.

According to Professor Andrew Pitsillides, who co-led the research at the Royal Veterinary College in London, “These initial results are very positive for such an experiment and we have convinced ourselves that sulforaphane is a promising agent for the treatment of osteoarthritis. However, the clinical development of sulforaphane has been held back by the fact that it is inherently unstable. Thus, SFX-01 is a major advance in this area… There is no cure or effective treatment for the disease other than pain relief or joint replacement, so the potential for SFX-01 is massive.”

Results from the study were presented recently at the 4th Joint Meeting of European Calcified Tissue Society (ECTS) and the International Bone and Mineral Society (IBMS) in Rotterdam.

#Osteoarthritis #BoneHealth #Broccoli #Sulforadex #Sulforophane #Arthritis

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This web site is run by an Arthritis Specialist based in Dubai, United Arab Emirates. On this site you will find news about the latest in arthritis, information about research results in the field, tips and information and diet and exercise, and much more.

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